L-Valine → Formylvaline

HRID 2287236ノート

反応式

HRID 2287236 の反応式
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].[CH:9](OC(=O)C)=[O:10]>C(O)=O>[CH:9]([NH:1][CH:2]([CH:3]([CH3:5])[CH3:4])[C:6]([OH:8])=[O:7])=[O:10]

参加物

4

反応物 2

HCID 6287L-ValineHCID 75269Acetic-formic anhydride

生成物 1

HCID 100123Formylvaline

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

To valine (15 g, 0.129 mol) in 88% formic acid (52 ml) is added acetic formic anhydride (33 g, 0.386 mol) over 0.75 hr at 5°. The reaction mixture is warmed to RT and stirred overnight. The reaction is worked up by distilling off (bath temp. 45°-50°) the solvent, excess anhydride and acetic acid, to give, as a white solid, 2-(N-formylamino)-3-methylbutanoic acid, recrystallized from hot ethanol, m.p. 143°-145°.

後処理

  1. distillationby distilling off (bath temp. 45°-50°) the solvent, excess anhydride and acetic acid

出典と根拠

ORDレコード
ord-857085133ae147fba7308af8127aa402
出典データセット
uspto-grants-1981_05
特許番号
US04269981

反応ノート

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