Dimethyl Sulfoxide → 1-(3-Methoxyphenyl)-2-pyridin-4-ylethane-1,2-dione
反応式
CS(C)=O.FC(F)(F)C(OC(=O)C(F)(F)F)=O.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:26]([OH:35])[CH:27]([C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[OH:28])[CH:23]=[CH:24][CH:25]=1.C(N(CC)CC)C.C(=O)([O-])O.[Na+]>ClCCl>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([C:26](=[O:35])[C:27]([C:29]2[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=2)=[O:28])[CH:23]=[CH:24][CH:25]=1参加物
反応条件
- 温度
- 0 °C
実験手順
To a stirring solution of methyl sulfoxide (11.8 g, 10.7 mL, 150 mmol) in dichloromethane (150 mL) at -78° C. was added trifluoroacetic anhydride (23.7 g, 16 mL, 113 mmol) dropwise. After ten minutes, 1-(3-methoxyphenyl)-2-pyridin-4-ylethane-1,2-diol (8.5 g, 34 mmol) in dichloromethane (60 mL) was added dropwise. Ater another ten minutes, triethylamine (21.3 g, 29.4 mL, 211 mmol) was added dropwise and the reaction mixture was immediately warmed to 0° C. and poured into saturated aqueous sodium hydrogen carbonate solution (300 mL). The aqueous layer was extracted with ethyl acetate (3×200 mL) and the organic layers were combined, dried over anhydrous magnesium sulfate and concentrated at reduced pressure. The resulting oil was chromatographed on silica gel eluting with 1:3 ethyl acetate:hexane to give the dione as a yellow solid (5.1 g).
後処理
- waitAfter ten minutes
- waitAter another ten minutes
- extractionThe aqueous layer was extracted with ethyl acetate (3×200 mL)
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated at reduced pressure
- customThe resulting oil was chromatographed on silica gel eluting with 1:3 ethyl acetate
出典と根拠
- ORDレコード
- ord-f32320826ee24af99077658873f8607f
- 出典データセット
- uspto-grants-2000_07
- 特許番号
- US06083949
反応ノート
読み込み中…