Dichloromethane → (3-Hydroxy-6-methyl-pyridin-2-yl)-phenyl-methanone

反応式

[OH:1][CH:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:3]1[C:8]([OH:9])=[CH:7][CH:6]=[C:5]([CH3:10])[N:4]=1.ClCCl>CO.[O-2].[O-2].[Mn+4]>[OH:9][C:8]1[C:3]([C:2]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:1])=[N:4][C:5]([CH3:10])=[CH:6][CH:7]=1

参加物

実験手順

2-(Hydroxy-phenyl-methyl)-6-methyl-pyridin-3-ol (553 mg) was dissolved in methanol (3 ml) and dichloromethane (9 ml) to prepare a solution. Manganese dioxide (2.05 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite and was then washed with chloroform and methanol. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-acetone to give (3-hydroxy-6-methyl-pyridin-2-yl)-phenyl-methanone (439 mg, yield 80%).