Ammonium Acetate → 5,6-Dimethyl-2-phenyl-pyridin-3-ol

HRID 228809

反応式

HRID 228809 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[O:5][C:6]=1[CH3:7].C([O-])(=O)C.[NH4+:20]>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:20][C:6]=1[CH3:7]

参加物

3

反応物 2

HCID 517165Ammonium AcetateHCID 23078263(4,5-Dimethylfuran-2-yl)-phenyl-methanone

生成物 1

HCID 230783805,6-Dimethyl-2-phenyl-pyridin-3-ol収率 16,079.1%

反応条件

温度
250 °C

実験手順

(4,5-Dimethylfuran-2-yl)-phenyl-methanone (1 g) and ammonium acetate (910 mg) were placed in a sealed tube, and the mixture was stirred at 250° C. for 10 hr. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-2-phenyl-pyridin-3-ol (160 g, yield 16%).

後処理

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-09edd896e4074eec884e88b7cdbc2141
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

読み込み中…