Ammonia → 5,6-Dimethyl-2-pyridin-2-yl-pyridin-3-ol

HRID 228812

反応式

HRID 228812 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:16]>CO>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[N:16][C:6]=1[CH3:7]

参加物

4

反応物 2

HCID 222AmmoniaHCID 23078484(4,5-Dimethylfuran-2-yl)-(2-pyridyl)-methanone

生成物 1

HCID 1356000565,6-Dimethyl-2-pyridin-2-yl-pyridin-3-ol収率 75%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
160 °C

実験手順

(4,5-Dimethylfuran-2-yl)-(2-pyridyl)-methanone (1.6 g), methanol (15 ml), and a 28% aqueous ammonia solution (15 ml) were placed in a sealed tube, and the mixture was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-[2,2′]-bipyridin-3-ol (1.2 g, yield 75%).

後処理

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-fcbb3681ca4446728a561ff7381997a1
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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