Ammonia → 5,6,5'-Trimethyl-[2,2']bipyridin-3-ol
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12](C)[N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:17].[CH3:18]O>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:18])=[CH:12][N:11]=2)=[N:17][C:6]=1[CH3:7]参加物
4
反応条件
- 温度
- 160 °C
実験手順
(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (780 mg), methanol (7 ml), and a 28% aqueous ammonia solution (7 ml) were placed in a sealed tube and were stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,5′-trimethyl-[2,2′]bipyridin-3-ol (529 mg, yield 68%).
後処理
- temperatureThe reaction solution was cooled to room temperature
- customthe solvent was then removed by distillation under the reduced pressure
- customthe residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-4bfe9740078f4312ab790b03d008545c
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07560558B2
反応ノート
読み込み中…