Sodium methanethiolate → 7-Pyridin-2-yl-isoquinolin-6-ol

HRID 228883ノート

反応式

HRID 228883 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH:9]=[N:8][CH:7]=[CH:6]2.C[S-].[Na+]>CN(C)C=O>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:12]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][C:3]=1[OH:2]

参加物

4

反応物 2

HCID 4378561Sodium methanethiolateHCID 230784766-Methoxy-7-pyridin-2-yl-isoquinoline

生成物 1

HCID 1358548277-Pyridin-2-yl-isoquinolin-6-ol収率 27%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
150 °C

実験手順

6-Methoxy-7-pyridin-2-yl-isoquinoline (118 mg) and sodium thiomethoxide (350 mg) were suspended in N,N-dimethylformamide (3 ml), and the mixture was stirred at 150° C. for 4 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 7-pyridin-2-yl-isoquinolin-6-ol (30 mg, yield 27%).

後処理

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe reaction solution was then filtered
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure
  4. customThe residue was purified by thin layer chromatography

出典と根拠

ORDレコード
ord-8075445007724bd081b256dfd0c1cf0e
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

反応ノート

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