Methyl 2-(2-hvdroxyethyl)indole-5-acetate → 2-(2-(4-(4-Chlorophenoxy)-2-propylphenoxy)ethyl)indole-5-acetic acid

反応式

[OH:1][CH2:2][CH2:3][C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=2.[Cl:18][C:19]1[CH:35]=[CH:34][C:22]([O:23][C:24]2[CH:29]=[CH:28][C:27](O)=[C:26]([CH2:31][CH2:32][CH3:33])[CH:25]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:35]=[CH:34][C:22]([O:23][C:24]2[CH:29]=[CH:28][C:27]([O:1][CH2:2][CH2:3][C:4]3[NH:5][C:6]4[C:11]([CH:12]=3)=[CH:10][C:9]([CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=4)=[C:26]([CH2:31][CH2:32][CH3:33])[CH:25]=2)=[CH:21][CH:20]=1

参加物

反応物 2

HCID 15462903Methyl 2-(2-hvdroxyethyl)indole-5-acetate

HCID 187722622-Propyl-4-(4-chlorophenoxy)phenol

生成物 1

HCID 154857532-(2-(4-(4-Chlorophenoxy)-2-propylphenoxy)ethyl)indole-5-acetic acid

実験手順

Using the procedures in Example 15, steps F and G, the title compound was prepared from methyl 2-(2-hydroxyethyl)indole-5-acetate and 4-(4-chlorophenoxy)-2-propylphenol.

出典と根拠

ORDレコード: ord-336d7667cffa49769112b8421f58cb92
出典データセット: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06090839

反応ノート

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