Pyrimidine → (S)-3-Methylpentyl methanesulfonate
反応式
[CH3:1][C@@H:2]([CH2:6][CH3:7])[CH2:3][CH2:4][OH:5].N1C=CC=NC=1.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([O:5][CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:6][CH3:7])(=[O:17])=[O:16]参加物
4
実験手順
In a flask were charged 15.89 g of (S)-3-methylpentanol and 65 ml of pyrimidine. After cooling to 0° to 50° C., 23.63 g of methanesulfonyl chloride was added thereto dropwise, and the mixture was allowed to react at the same temperature for 1 hour. The reaction mixture was extracted with diethyl ether, and the extract was washed with water and concentrated to obtain 12.14 g (46.42%) of the titled compound.
後処理
- temperatureAfter cooling to 0° to 50° C.
- customto react at the same temperature for 1 hour
- extractionThe reaction mixture was extracted with diethyl ether
- washthe extract was washed with water
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5da116c9920b45c5b94894bd56232f10
- 出典データセット
- uspto-grants-2000_07
- 特許番号
- US06093345
反応ノート
読み込み中…