Methanol → HCID 57062068、化合物
反応式
CO.[CH3:3][C@H:4]([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:5][C:6](=[O:15])[CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>C(Cl)Cl>[OH:15][C@@H:6]([CH2:5][C@H:4]([CH3:3])[CH2:16][CH2:17][CH2:18][CH3:19])[CH2:7][C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9]参加物
4
実験手順
In a 200 ml autoclave were charged 50 ml of methanol, 14.0 g of t-butyl (R)-5-methyl-3-oxononanoate obtained in Step 5, and a solution of 0.49 g of (S)-di[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]tetrachlorodiruthenium triethylamine in 40 ml of methylene chloride, and the mixture was allowed to react under a hydrogen pressure of 60 kg/cm2 for 18 hours. The solvent was removed by distillation under reduced pressure to obtain 13.6 g of a crude product, which was then purified by silica gel column chromatography to obtain 10.3 g (72.5%) of the titled compound.