Hydrochloric Acid → HCID 24847455、化合物

HRID 2289418

反応式

HRID 2289418 の反応式
[ClH:1].[CH3:2][C@@:3]([C:13]([OH:15])=[O:14])([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[NH2:4].[CH3:16]O>>[ClH:1].[CH3:16][O:14][C:13](=[O:15])[C@:3]([CH3:2])([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[NH2:4]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 441350Metyrosine

生成物 1

HCID 24847455HCID 24847455、化合物収率 100%

実験手順

Anhydrous hydrogen chloride was bubbled through a solution of α-methyl-L-tyrosine (1 g, 5.13 mmol) in methanol (100 ml) for a few minutes and the solution stirred at room temeprature for 48 h. The solvent was evaporated in vacuo and the residue freeze dried from a mixture of methanol and water to give the title compound as a white powder (1.28 g, 100%); δH (CD3OD) 7.00 (2H, d, J 8.6 Hz, ArH), 6.78 (2H, d, J 8.6 Hz, ArH), 3.82 (3H, s, CO2CH3), 3.19 (1H, d, J 14.3 Hz, CHAHBAr), 3.01 (1H, d, J 14.3 Hz, CHAHBAr) and 1.59 (3H, s, CCH3); m/z (ES, 27V) 210 (M+ +1).

後処理

  1. customThe solvent was evaporated in vacuo
  2. dry with materialthe residue freeze dried from a mixture of methanol and water

出典と根拠

ORDレコード
ord-6605b8bf3da4442babab6bcdcbf37ab6
出典データセット
uspto-grants-2000_07
特許番号
US06093696

関連ノート

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