4,6-Dichloro-2-ethylpyrimidine → 1-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

HRID 2289550ノート

反応式

HRID 2289550 の反応式
[CH3:1][C:2]1([C:8]([O:10]CC)=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:13]([C:15]1[N:20]=[C:19](Cl)[CH:18]=[C:17](Cl)[N:16]=1)[CH3:14]>C(O)C.CCN(CC)CC>[CH2:13]([C:15]1[N:20]=[C:19]([N:5]2[CH2:4][CH2:3][C:2]([CH3:1])([C:8]([OH:10])=[O:9])[CH2:7][CH2:6]2)[CH:18]=[CH:17][N:16]=1)[CH3:14]

参加物

5

反応物 2

HCID 5184654,6-Dichloro-2-ethylpyrimidineHCID 19361805Ethyl 4-methylpiperidine-4-carboxylate

生成物 1

HCID 186980471-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 8471Triethylamine溶媒

実験手順

1-(2-Ethylpyrimidin-4yl)-4-methyl-piperidine-4-carboxylic acid was prepared on a 3 mmol 4-methyl-4-ethoxycarbonyl-piperidine (as TFA salt) in 7 ml ethanol and 1 ml Et3N treated with a solution of 0.531 g 2-ethyl-4,6-dichloropyrimidine in 4 ml ethanol. After 20 hours at ambient temp. The ethanol was removed and the residue partitioned between water and ethanol, washed with sodium hydrogen carbonate solution and brine. Evaporated to give gum (88.3%).

後処理

  1. customThe ethanol was removed
  2. customthe residue partitioned between water and ethanol
  3. washwashed with sodium hydrogen carbonate solution and brine
  4. customEvaporated

出典と根拠

ORDレコード
ord-612357af215049ceae5b4f7b5693025e
出典データセット
uspto-grants-2000_07
特許番号
US06093718

反応ノート

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