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Itaconic acid → 5-Oxo-1-(3-{(benzylamino)carbonylamino}-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Itaconic acid | HCID 811 | — |
| 反応物 | n-(3-Amino-5-(trifluoromethyl)phenyl)(benzylamino)carboxamide | HCID 22591859 | — |
| 生成物 | 5-Oxo-1-(3-{(benzylamino)carbonylamino}-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid | HCID 22591872 | — |
反応手順
A mixture of N-(3-amino-5-(trifluoromethyl)phenyl)(benzylamino)carboxamide and itaconic acid was fused at 110° C. for 10 hours. The resulted solid was washed with methanol and then dried at 50° C. for 12 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849639B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-864cef6e6f664a059be8b4a512c33fb1 |
| 出典メモ | uspto-grants-2005_02 |