Hydrochloric Acid → 3-[(1-methyl-1H-tetrazol-5-yl)thio]propanoic acid
反応式
C([O:3][C:4](=[O:14])[CH2:5][CH2:6][S:7][C:8]1[N:12]([CH3:13])[N:11]=[N:10][N:9]=1)C.Cl.O>C(O)(=O)C>[CH3:13][N:12]1[C:8]([S:7][CH2:6][CH2:5][C:4]([OH:14])=[O:3])=[N:9][N:10]=[N:11]1参加物
5
実験手順
5.43 g of 3-(1-methyltetrazol-5-ylthio)-propionic acid ethyl ester are dissolved in 20 ml of acetic acid, 4 ml of conc. HCl and 8 ml of water and the whole is stirred for 3.5 hours at 100°. After concentration of the reaction mixture by evaporation, the residue is partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The aqueous phase is separated off, acidified with 4N HCl and extracted twice with ethyl acetate. After drying and concentration by evaporation the title compound is obtained.
後処理
- customAfter concentration of the reaction mixture by evaporation
- customthe residue is partitioned between ethyl acetate and aqueous sodium bicarbonate solution
- customThe aqueous phase is separated off
- extractionextracted twice with ethyl acetate
- customAfter drying
- concentrationconcentration
- customby evaporation the title compound
- customis obtained
出典と根拠
- ORDレコード
- ord-0f2625481ec04d85a6e0f636a07339d5
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04616007
反応ノート
読み込み中…