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HRID 2290238作成日：2026年10月27日
2-((4-Chlorophenoxy)methyl)oxirane → 1-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl]piperazine
https://huagongshe.com/reaction/2290238
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-((4-Chlorophenoxy)methyl)oxirane | HCID 91515 | — |
| 反応物 | 1-(3-Fluoro-2-pyridinyl)piperazine | HCID 134987 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl]piperazine | HCID 20232175 | 81% |
反応手順
To 1-(3-fluoro-2-pyridyl)piperazine (453 mg, 2.5 mmol) in 5 ml of isopropanol stirred under nitrogen at 70° C. was added 4-chlorophenoxy-2,3-epoxypropane (476 mg, 2.5 mmol) portionwise and the solution stirred at 70° C. for 3 hours The solution was concentrated in vacuo and the residual oil chromatographed on silica gel eluting with 5% methanol-chloroform to yield 740 mg (81%) of 1-[3-(4-chlorophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl]piperazine; m.p. 73°-76° C. Analysis satisfactory for C18H21ClFN3O2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04616017 |
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| 出典データセット | uspto-grants-1986_10 |
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| ORD ID | ord-fa35163cc57f44ae8a425d1bdca09f5d |
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| 出典メモ | uspto-grants-1986_10 |
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