Methanethiol → {3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

HRID 2290260ノート

反応式

HRID 2290260 の反応式
CS(=[N:7][C:8]#[N:9])C(=S)OC.[CH3:10][O:11][C:12]1[CH:22]=[CH:21][C:15]([CH2:16][NH:17][CH2:18][CH2:19][SH:20])=[CH:14][CH:13]=1.[CH3:23]S>C(O)C>[C:8]([N:7]=[C:23]1[N:17]([CH2:16][C:15]2[CH:21]=[CH:22][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[CH2:18][CH2:19][S:20]1)#[N:9]

参加物

5

反応物 3

HCID 878MethanethiolHCID 14306201N-(4-methoxybenzyl)-cysteamineHCID 87522899Cyanimino-dithiocarbonic acid dimethylester

生成物 1

HCID 14306204{3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3.65 g (23.5 moles) of cyanimino-dithiocarbonic acid dimethylester (purity: 94%) and 5.91 (30 moles) of N-(4-methoxybenzyl)-cysteamine are boiled in 30 ml of ethanol until the evolution of methyl mercaptan terminates. The reaction mixture is evaporated and the crystalline residue is recrystallized from 15 ml of isopropanol. 5.35 g (92%) of 2-cyanimino-3-(4-methoxybenzyl)-thiazolidine are obtained, melting at 99° to 102° C.

後処理

  1. customThe reaction mixture is evaporated
  2. customthe crystalline residue is recrystallized from 15 ml of isopropanol

出典と根拠

ORDレコード
ord-da11e47810b3438c9a5b4916232a9061
出典データセット
uspto-grants-1986_10
特許番号
US04616025

反応ノート

読み込み中…