Ammonium Hydroxide → 2-Cyanimino-3-(4-hydroxy-benzyl)-thiazolidine

HRID 2290262ノート

反応式

HRID 2290262 の反応式
[C:1]([N:3]=[C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)[CH2:7][CH2:6][S:5]1)#[N:2].[OH-].[NH4+]>ClCCl>[C:1]([N:3]=[C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH2:7][CH2:6][S:5]1)#[N:2]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 14306204{3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

生成物 1

HCID 143062082-Cyanimino-3-(4-hydroxy-benzyl)-thiazolidine収率 0%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

0.49 g (2 moles) of 2-cyanimino-3-(4-methoxybenzyl)-thiazolidine are dissolved in 12 ml of dichloromethane and a solution of 3.01 g (1.14 ml, 13 mmoles) of borotribromide in 5 ml of dichloromethane is added in an argon atmosphere, dropwise. The mixture is stirred for 12 hours and is then alkalized with an aqueous ammonium hydroxide solution, under stirring and cooling. The phases are separated and the organic phase is evaporated. 0.22 g of 2-cyanimino-3-(4-hydroxy-benzyl)-thiazolidine are obtained in a white crystalline form, melting at 175° to 177° C.

後処理

  1. stirringunder stirring
  2. temperaturecooling
  3. customThe phases are separated
  4. customthe organic phase is evaporated

出典と根拠

ORDレコード
ord-381a7baed05e437f92d1bca03ee64567
出典データセット
uspto-grants-1986_10
特許番号
US04616025

反応ノート

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