Methanol → HCID 136332165、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9](=[N:11][OH:12])[CH3:10])=[CH:4][CH:3]=1.[NH2:14][NH:15][C:16]([NH2:18])=[S:17].CO>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:14][NH:15][C:16]([NH2:18])=[S:17])[C:9](=[N:11][OH:12])[CH3:10])=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 4'-chloro-2-hydroxyiminopropiophenone (252.3 g), thiosemicarbazide (151.3 g), methanol (650 ml) water (300 ml), and acetic acid (9 ml) was refluxed for 31 hours with stirring. After cooling, the resulting precipitates were collected by filtration, washed successively with methanol, water and methanol, and then dried to give 4'-chloro-2-hydroxyiminopropiophenone thiosemicarbazone (298.88 g).
後処理
- temperaturewas refluxed for 31 hours
- temperatureAfter cooling
- customthe resulting precipitates
- filtrationwere collected by filtration
- washwashed successively with methanol, water and methanol
- customdried
出典と根拠
- ORDレコード
- ord-d460d2d077154021a548584d4355b394
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04616014
反応ノート
読み込み中…