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Piperazine Dihydrochloride → Methyl 4-[(piperazin-1-yl)methyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine Dihydrochloride | HCID 8893 | — |
| 反応物 | Piperazine, hexahydrate | HCID 120181 | — |
| 反応物 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-[(piperazin-1-yl)methyl]benzoate | HCID 7018627 | 64% |
反応手順
A mixtue of 38 g. (0.2 mole) piperazine hexahydrate, 28 g. (0.2 mole) piperazine dihydrochloride and 150 ml. methanol is mixed, while stirring at ambient temperature, with 45 g. (0.2 mole) methyl 4-bromomethylbenzoate. The reaction mixture is left to stand for 2 days and suction filtered from the precipitate. The clear solution is evaporated and the residue is recrystallised from ethanol to give 39 g. (64%) of the desired compound as a monohydrochloride; m.p. 226°-227° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04616086 |
| 出典データセット | uspto-grants-1986_10 |
| ORD ID | ord-c2a1209efed14541a56982e6500c44bc |
| 出典メモ | uspto-grants-1986_10 |