Potassium Carbonate → Piritetrate

HRID 2290608

反応式

HRID 2290608 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][CH3:10])[N:4]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:18]([O:20][C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=1)=[S:19]>CC(C)=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]([N:9]([CH3:10])[C:18](=[S:19])[O:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 82681O-2-Naphthyl chlorothioformateHCID 70191686-methoxy-N-methylpyridin-2-amine

生成物 1

HCID 145908Piritetrate収率 84.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

To the mixture of 1.38 g of 2-methoxy-6-methylaminopyridine, which is one of the compounds of this invention, and the same amount of anhydrous potassium carbonate in 20 ml of acetone, 2.23 g of O-2-naphthyl chlorothioformate dissolved in 20 ml of acetone was added under stirring at room temperature. After 30 minutes, the reaction mixture was extracted with benzene, washed with water, dried and recrystallized to give 2.75 g of O-2-naphthyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate.

後処理

  1. additionwas added
  2. extractionthe reaction mixture was extracted with benzene
  3. washwashed with water
  4. customdried
  5. customrecrystallized

出典と根拠

ORDレコード
ord-e353faaeb4a345408ac3d62c39eb4382
出典データセット
uspto-grants-1986_10
特許番号
US04617397

関連ノート

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