Sulfuric Acid → HCID 178433476、化合物
反応式
S(=O)(=O)(O)[OH:2].[CH3:6][C:7]1[N:12]=[C:11](Cl)[C:10]([F:14])=[C:9]([Cl:15])[N:8]=1.[Cl-].[Na+]>O>[CH3:6][C:7]1[N:12]=[C:11]([OH:2])[C:10]([F:14])=[C:9]([Cl:15])[N:8]=1参加物
5
実験手順
To a mixture of water (3 mL) and concentrated sulfuric acid (7 mL) was added 1.81 g (10 mmol) of 2-methyl-4,6-dichloro-5-fluoropyrimidine. The reaction mixture was stirred for 3 hours and then poured onto ice. The mixture was saturated with sodium chloride and extracted with ethyl acetate. The organic extracts were combined, dried (MgSO4), filtered, and concentrated in vacuo to give crude product (1.4 g, 86%), m.p. 214°-216° C. This product was used in subsequent reactions without further purification.
後処理
- additionpoured onto ice
- extractionextracted with ethyl acetate
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-e674853e7e3c4ca8812fe602d86d5049
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04617393
反応ノート
読み込み中…