Triethylamine → HCID 20229919、化合物

HRID 2290690ノート

反応式

HRID 2290690 の反応式
[OH:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1.C(N(CC)CC)C.[C:14]([C:16]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:27]=2[Cl:33])=[CH:21][C:17]=1[C:18](Cl)=[O:19])#[N:15]>C1(C)C=CC=CC=1>[C:14]([C:16]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:27]=2[Cl:33])=[CH:21][C:17]=1[C:18]([O:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1)=[O:19])#[N:15]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 99603-Furanol, tetrahydro-HCID 202299172-Cyano-5-(2,4-dichlorophenoxy)benzoyl chloride

生成物 1

HCID 20229919HCID 20229919、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

3-Hydroxytetrahydrofuran (0.04 mole), toluene (50 ml) and triethylamine (0.04 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and addition funnel. A solution of 2-cyano-5-(2,4-dichlorophenoxy)benzoyl chloride (0.04 mole) in toluene (20 ml) is slowly added at room temperature with stirring. After the addition is completed, stirring is continued for a period of about eight hours. After this time, the reaction mixture is washed with water and dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent under reduced pressure leaving a residue. This residue is purified by silica gel chromatography using toluene and ethyl acetate/toluene mixture as the eluant to yield the desired product 3-tetrahydrofuryl 2-cyano-5-(2,4l -dichlorophenoxy)benzoate.

後処理

  1. customequipped with a mechanical stirrer and addition funnel
  2. additionAfter the addition
  3. stirringstirring
  4. washAfter this time, the reaction mixture is washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customleaving a residue
  7. customThis residue is purified by silica gel chromatography

出典と根拠

ORDレコード
ord-bba52bd40bdc4aaf804e3c8882e1f62a
出典データセット
uspto-grants-1986_10
特許番号
US04618359

反応ノート

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