関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 反応物 | Sodium methanesulfinate | HCID 2733271 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-Fluoro-1-(methylsulfonyl)-4-nitrobenzene | HCID 22316781 | 79% |
反応手順
8 g of 3,4-difluoronitrobenzene and 1.01 eq of sodium methanesulfinate (95%) was dissolved in 10 ml of DMSO. The solution was stirred at 60° C. for 3 hours. When the reaction was completed, the solution was added to 100 ml of water to form pale yellow solid, followed by filtration and washing with 50 ml of cool water and 30 ml of n-hexane separately to give 8.8 g of the title compound as a pale yellow solid (yield 79%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06849652B1 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-d65540f051e14807a858c381dcb08832 |
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| 出典メモ | uspto-grants-2005_02 |
|---|
