化工社化工社 化学情報印刷レポート · 研究参考用
Acetylene → 17alpha-Ethynyl-17beta-hydroxy-16beta-methylandrosta-1,4,9(11)-trien-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetylene | HCID 6326 | — |
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | 16beta-Methylandrosta-1,4,9(11)-triene-3,17-dione | HCID 13518558 | — |
| 反応物 | acetylene THF | HCID 67285190 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 17alpha-Ethynyl-17beta-hydroxy-16beta-methylandrosta-1,4,9(11)-trien-3-one | HCID 86740176 | — |
反応手順
Dry THF (5 l) is cooled to -20° and acetylene (0.27 kg) is dissolved in the THF at -20°. Diisopropylamine (880 ml) is added to the acetylene/THF solution. n-Butyllithium (1.6M, 3.88 l) is added to the mixture maintaining the temperature at -20° and stirred for 30 min. 16β-Methylandrosta-1,4,9(11)-triene-3,17-dione (IB) in (THF) is added to the reaction mixture at or below -20° and stirred for 20 min to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04618456 |
| 出典データセット | uspto-grants-1986_10 |
| ORD ID | ord-75b00166997b4d7cb807282f56dc8d9e |
| 出典メモ | uspto-grants-1986_10 |