化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 3-(4-Phenethylpiperazin-1-yl)propanethiol dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153179 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(4-Phenethylpiperazin-1-yl)propanethiol dihydrochloride | HCID 13731124 | 81.6% |
反応手順
The procedure described in Example 1(b) was followed, using 15.2 g of thiourea, 32.6 g of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride, 20.0 g of triethylamine and 250 ml of reagent ethanol The hydrolysis was effected with 10.0 g of sodium hydroxide in 40 ml of water. Work-up, as described above, gave 26.4 g (79% of theory) of 3-(4-phenethylpiperazin-1-yl)propanethiol dihydrochloride as an off-white crystalline solid, M.p. 269°-272° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04618677 |
| 出典データセット | uspto-grants-1986_10 |
| ORD ID | ord-da3c67e0d34b4311af46b8b83e33b12f |
| 出典メモ | uspto-grants-1986_10 |