1-Bromo-3-chloropropane → 1-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

HRID 2290875

反応式

HRID 2290875 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:19][CH2:20][CH2:21][Cl:22]>CS(C)=O>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][N:11]([CH2:19][CH2:20][CH2:21][Cl:22])[CH2:10][CH2:9]2)=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 122357141-[2-(4-Chlorophenyl)ethyl]piperazine

生成物 1

HCID 201531821-(4-Chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride収率 118.3%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The procedure described in Example 17(a) was followed, using 6.5 g of 1-(4-chlorophenethyl)piperazine, 6.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 4.6 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 6.4 g (59% of theory) of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

出典と根拠

ORDレコード
ord-7b80716b45d64e679201511e1525b033
出典データセット
uspto-grants-1986_10
特許番号
US04618677

関連ノート

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