Methyl Isocyanate → HCID 13690936、化合物

HRID 2290988ノート

反応式

HRID 2290988 の反応式
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:12])=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:7]=1.[CH3:13][N:14]=[C:15]=[O:16]>C(Cl)Cl.C(N(CC)CC)C>[Cl:12][C:5]1[N:4]=[N:3][C:2]([NH:1][C:15]([NH:14][CH3:13])=[O:16])=[CH:7][C:6]=1[C:8]([CH3:9])([CH3:11])[CH3:10]

参加物

5

反応物 2

HCID 12228Methyl Isocyanate2 回HCID 1637143-Pyridazinamine, 6-chloro-5-(1,1-dimethylethyl)-

生成物 1

HCID 13690936HCID 13690936、化合物

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a mixture of 1.3 g of (0.007 mole) of 3-amino-6-chloro-5-(1,1-dimethylethyl)pyridazine in 65 ml of methylene chloride was added one drop of triethylamine and 0.8 g (0.014 mole, 2.0 equivalents) of methyl isocyanate. The mixture was stirred at room temperature for about 18 hours. Additional methyl isocyanate (0.8 g, 0.140 mole, 2.0 equivalents) was added and about 3 hours later, the solution was diluted to 400 ml using methylene chloride. The solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water, and was then dried with magnesium sulfate.

後処理

  1. additionthe solution was diluted to 400 ml
  2. washThe solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water
  3. dry with materialwas then dried with magnesium sulfate

出典と根拠

ORDレコード
ord-a1a9d47bb9404b8085f177c37bb72548
出典データセット
uspto-grants-1986_10
特許番号
US04619686

反応ノート

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