化工社化工社 化学情報印刷レポート · 研究参考用
Methyl Acetate → HCID 68863785、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acetate | HCID 6584 | — |
| 反応物 | 6-Methyl-2-pyridinecarboxaldehyde | HCID 70737 | — |
| 反応物 | 2-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 2736672 | — |
| 反応物 | Ether hydrochloride | HCID 10953452 | — |
| 反応物 | (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}phenyl)acetic acid | HCID 68862792 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | HCID 68863785 | HCID 68863785 | — |
反応手順
Following the procedure of Example 7(d) except (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}-phenyl)acetic acid and 6-methyl-2-pyridinecarboxaldehyde were used instead of (R)-2-(3-{3-(2,2-diphenylethyl)amino]-3-methyl-propoxy}phenyl)acetic acid methyl ester and 2-chloro-3-trifluoromethylbenzaldehyde in step (d) the corresponding carboxylic acid was obtained. The resulting amine/carboxylic acid was dissolved in Et2O (diethylether) and acidified with 1.0 M HCl/Et2O. The reaction mixture was concentrated in vacuo and dried under reduced pressure to give the title compound as a white solid, 89 mg (95%). MS (ESI) 509.4 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560586B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-3fd52f9b388045c7a33bc72b36a31676 |
| 出典メモ | uspto-grants-2009_07 |