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Methyl Acetate → (r)-2-(3-{3-[[4-Methoxy-benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)acetic acid hydrochloride salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acetate | HCID 6584 | — |
| 反応物 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 反応物 | 2-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 2736672 | — |
| 反応物 | Ether hydrochloride | HCID 10953452 | — |
| 反応物 | (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}phenyl)acetic acid | HCID 68862792 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | (r)-2-(3-{3-[[4-Methoxy-benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)acetic acid hydrochloride salt | HCID 68863515 | — |
反応手順
Following the procedure of Example 7(d) except (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}phenyl)acetic acid and 4-methoxybenzaldehyde were used instead of (R)-2-(3-{3-(2,2-diphenylethyl)amino]-3-methyl-propoxy}-phenyl)acetic acid methyl ester and 2-chloro-3-trifluoromethylbenzaldehyde in step (d) the corresponding carboxylic acid was obtained. The resulting amine/carboxylic acid was dissolved in Et2O (diethylether) and acidified with 1.0 M HCl/Et2O. The reaction mixture was concentrated in vacuo and dried under reduced pressure to give the title compound as a white solid, 94 mg (97%). MS (ESI) 524.4 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560586B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-44de05aac8344a81af2c8d0345dda63e |
| 出典メモ | uspto-grants-2009_07 |