Sulfuric Acid → 3,5-Dibromopyrazin-2(1H)-one

HRID 2291229ノート

反応式

HRID 2291229 の反応式
N[C:2]1[C:7]([Br:8])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.S(=O)(=O)(O)[OH:11].N([O-])=O.[Na+]>>[Br:8][C:7]1[C:2](=[O:11])[NH:3][CH:4]=[C:5]([Br:9])[N:6]=1

参加物

4

反応物 3

HCID 1118Sulfuric Acid2 回HCID 6200042-Amino-3,5-dibromopyrazineHCID 23668193Sodium Nitrite

生成物 1

HCID 167408633,5-Dibromopyrazin-2(1H)-one

反応条件

温度
20 °C

実験手順

A solution of 12.65 g of 2-amino-3,5-dibromo-pyrazine and 18.5 ml of 96% sulfuric acid is added dropwise to a solution of 3.45 g of sodium nitrite and 27.5 ml of 96% sulfuric acid at 0° to 5° C. The mixture is then allowed to warm to 20° C. in the course of 2 hours and is stirred at 20°-25° C. for a further 15 hours. The reaction mixture is poured into ice and the product is filtered off, washed with ice-water and dried to give 5.8 g of 3,5-dibromo-pyrazin-2-one.

後処理

  1. additionThe reaction mixture is poured into ice
  2. filtrationthe product is filtered off
  3. washwashed with ice-water
  4. customdried

出典と根拠

ORDレコード
ord-220ce1ff5f4e47a58d228edc0112a934
出典データセット
uspto-grants-1989_01
特許番号
US04795486

反応ノート

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