化工社化工社 化学情報印刷レポート · 研究参考用
rel-(2R,6S)-2,6-dimethylpiperazine → Sparfloxacin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| 反応物 | 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13910947 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Sparfloxacin | HCID 60464 | — |
反応手順
In the same manner as described in Example 1 (1), a mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, cis-2,6-dimethylpiperazine, and dimethylformamide was stirred at room temperature for 24 hours to give 5-amino-1-cyclopropyl-6,8-difluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, m.p. 258°-260° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04795751 |
| 出典データセット | uspto-grants-1989_01 |
| ORD ID | ord-1e5b3746ca5e42739940983132139e2b |
| 出典メモ | uspto-grants-1989_01 |