Ammonia → 4-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

HRID 2291321ノート

反応式

HRID 2291321 の反応式
[F:1][C:2]([F:21])([F:20])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.[NH3:22]>CCO>[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 537498974-[2-(3-[2,2,2-Trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile

生成物 1

HCID 212797494-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-[2-(3-[2,2,2-trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile (29 g.), yellow mercuric oxide (29 g.) and a saturated solution of ammonia in EtOH (100 ml.) was stirred at room temperature for 24 hours and then filtered. The filtrate was evaporated to dryness and the residue triturated with petroleum ether (b.p. 60°-80°) and collected to give 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile (24 g.), m.p. 89°-91°.

後処理

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. customthe residue triturated with petroleum ether (b.p. 60°-80°)
  4. customcollected

出典と根拠

ORDレコード
ord-d116a4c989cc4fb8b8e39baf6176460c
出典データセット
uspto-grants-1989_01
特許番号
US04795755

反応ノート

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