4-Methanesulphonamidophenethyl mesylate → HCID 21278924、化合物

HRID 2291569ノート

反応式

HRID 2291569 の反応式
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=1)(=O)=O.[CH3:19][S:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[CH:26][C:25]=1[CH3:36])(=[O:22])=[O:21]>C(O)C>[CH3:19][S:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][N:33]([CH2:6][CH2:7][C:8]3[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:12][CH:13]=3)[CH2:32][CH2:31]2)=[CH:26][C:25]=1[CH3:36])(=[O:21])=[O:22]

参加物

4

反応物 2

HCID 149859624-Methanesulphonamidophenethyl mesylateHCID 54529973HCID 54529973、化合物

生成物 1

HCID 21278924HCID 21278924、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Methanesulphonamidophenethyl methanesulphonate (1.47 g) and 1-(4-methanesulphonamido-3-methylphenyl)piperazine 1/4 hydrate (1.37 g) in ethanol (15 ml) were refluxed overnight, evaporated to dryness, and partitioned between ethyl acetate and water. The title compound (0.2 g) was filtered from the 2-phase mixture and recrystallised from methanol/acetone, yield 0.128 g, m.p. 235°-7°.

後処理

  1. customevaporated to dryness
  2. custompartitioned between ethyl acetate and water
  3. filtrationThe title compound (0.2 g) was filtered from the 2-phase mixture
  4. customrecrystallised from methanol/acetone, yield 0.128 g, m.p. 235°-7°

出典と根拠

ORDレコード
ord-6e52fb03d0be4542964729bf1f2d6de9
出典データセット
uspto-grants-1989_01
特許番号
US04797401

反応ノート

読み込み中…