Hydrochloric Acid → N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

HRID 2291572ノート

反応式

HRID 2291572 の反応式
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][S:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:15][CH:14]=1)(=[O:18])=[O:19]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 21278916N-[4-(4-Acetylpiperazin-1-yl)phenyl]methanesulfonamide

生成物 1

HCID 18759927N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

実験手順

1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).

後処理

  1. customthe solvent was evaporated
  2. customthe residue dried
  3. customby azeotroping with toluene
  4. customThe residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.)

出典と根拠

ORDレコード
ord-dc7e346d058b47e6802b42e091e5a229
出典データセット
uspto-grants-1989_01
特許番号
US04797401

反応ノート

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