関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-Methylquinoline | HCID 7059 | — |
| 反応物 | Pentane | HCID 8003 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Selenium Dioxide | HCID 24007 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-Quinolinecarbaldehyde | HCID 765653 | 21.5% |
反応手順
6-Methyl-quinoline (Aldrich Chemical Co.) (1 g, 7.0 mmol) and selenium dioxide (2.32 g, 21.0 mmol) were combined in the absence of solvent and heated at 100° C. under a nitrogen atmosphere for 16 h. The reaction mixture was allowed to cool to room temperature, taken up in MeOH and presorbed onto silica gel. Chromatography using a 3:1 mixture of pentane: EtOAc provided the title product (236 mg, 21%); 1HNMR (400 MHz, CDCl3) δ: 7.46-7.52 (m, 2H), 7.98 (d, 1H), 8.33-8.37 (m, 2H), 9.03 (d, 1H), 10.18 (s, 1H); m/z (ES+) 315 (2MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06849649B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-f0e5f8f1f26f46a1b8c680a466a37ac9 |
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| 出典メモ | uspto-grants-2005_02 |
|---|
