化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2291647作成日：2026年10月27日
Isopropyl chloroacetate → 1,2-Benzisothiazole-2(3H)-acetic acid, 3-oxo-, 1-methylethyl ester, 1,1-dioxide
https://huagongshe.com/reaction/2291647
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropyl chloroacetate | HCID 7759 | — |
| 反応物 | CID 46942257 | HCID 46942257 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,2-Benzisothiazole-2(3H)-acetic acid, 3-oxo-, 1-methylethyl ester, 1,1-dioxide | HCID 4519624 | 86.4% |
反応手順
23.3 kg (170.6 mol) of isopropyl chloroacetate are added to a solution at 50° C. of 40 kg (165.8 mol) of saccharin sodium dihydrate in 40 l of dimethylformamide. The mixture is heated to 120° C. and maintained for 3 hours at this temperature. The mixture is cooled and diluted with 240 l of water. Finally, the precipitate is centrifuged, washed with cold water and dried, 40.6 kg (86%) of a crystalline white solid, m.p. 112°-7° C. (118°-9° C. from isopropanol), being obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04797483 |
|---|
| 出典データセット | uspto-grants-1989_01 |
|---|
| ORD ID | ord-41b46a753549454fb63a8d871b97e157 |
|---|
| 出典メモ | uspto-grants-1989_01 |
|---|
