Aniline → Diethyl 2-(phenylamino)fumarate

HRID 2291799ノート

反応式

HRID 2291799 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:9][C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=O>C1(C)C=CC=CC=1>[C:2]1([NH:1][C:9]([C:8]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 66951Diethyl oxalacetate

生成物 1

HCID 588882Diethyl 2-(phenylamino)fumarate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Aniline (0.217 mol) and diethyl oxalacetate (0.217 mol) are mixed in toluene (500 m) and heated to reflux, i.e., about 100° C., under a water separator for approximately one hour. The toluene is then removed under vacuum to afford the desired product, i.e., diethyl 3-phenylaminobut-2-ene-dioate.

後処理

  1. temperatureheated
  2. temperatureto reflux
  3. customThe toluene is then removed under vacuum

出典と根拠

ORDレコード
ord-bceeb1efc46c43819dfb149a0fa8514c
出典データセット
uspto-grants-1989_01
特許番号
US04798619

反応ノート

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