Hydrochloric Acid → 9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine hydrochloride
反応式
[OH:1][CH2:2][CH2:3][CH:4]([CH2:17][OH:18])[CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.C(OCC(COCC1C=CC=CC=1)CCO)C1C=CC=CC=1.[ClH:41]>C(O)C>[ClH:41].[OH:1][CH2:2][CH2:3][CH:4]([CH2:17][OH:18])[CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2参加物
5
実験手順
9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine (46 mg; Example 1) was dissolved in 0.4 ml of 1M aqueous hydrochloric acid and the solution was lyophilized (0.1 mm Hg) over-night. The residue (53 mg, quantitive yield) was dissolved in a few drops of warm ethanol and precipitated with several volumes of tetrahydrofuran to yield a white, crystalline product. M.p. ~85° C. (d).