Water → HCID 13936026、化合物
反応式
ClC1C=C(C=CC=1)C([O:7][CH:8]1[C:13](=[O:14])[NH:12][C:11]([CH3:15])=[C:10]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[S:9]1)=O.O>CC(C)=O>[OH:7][CH:8]1[C:13](=[O:14])[NH:12][C:11]([CH3:15])=[C:10]([C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)[S:9]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
2-(3-Chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (1.37 g) and water (1 ml) were dissolved in acetone (20 ml) and the mixture was stirred at 70° C. for 44 hours. The mixture was chromatographed on silica gel (Wakogel C-200) column, using chloroform-methanol (=30:1) as an eluant to give the titled compound (0.16 g, yield 19.1%) as red needles.
後処理
- customThe mixture was chromatographed on silica gel (Wakogel C-200) column
出典と根拠
- ORDレコード
- ord-8660305a14e94d238bc41e0a5ee276c2
- 出典データセット
- uspto-grants-1989_01
- 特許番号
- US04800201
反応ノート
読み込み中…