Phosphorus oxychloride → 1-chloro-3-phenylisoquinoline
反応式
[C:1]1([C:7]2[N:8]=[CH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[Cl:19][C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:16]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1参加物
4
実験手順
3-Phenylisoquinoline (5 g) was dissolved in dry toluene (250 ml) and phosphorus oxychloride (16.52 g) was added and the mixture was heated at reflux for 48 hr, more phosphorus oxychloride (4 g) being added after 24 hr. The solvent was removed in vacuo to give 1-chloro-3-phenylisoquinoline as an oil which solidified on standing (4 g), characterised by its nmr spectrum. (A small portion was recrystallised from methanol, m.pt. 75°-77°).
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 48 hr
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-016b2b74af324dfabbb27fecea12c013
- 出典データセット
- uspto-grants-1989_01
- 特許番号
- US04801593
反応ノート
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