Triisopropyl borate → (2,3-Difluoro-4-nonylphenyl)boronic acid

反応式

[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C([Li])CCC.[B:23](OC(C)C)([O:28]C(C)C)[O:24]C(C)C>>[CH2:9]([C:3]1[CH:4]=[CH:5][C:6]([B:23]([OH:28])[OH:24])=[C:7]([F:8])[C:2]=1[F:1])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

反応物 3

HCID 21531Triisopropyl borate

HCID 21477978HCID 21477978、化合物

HCID 178418339Butyllithium

生成物 1

HCID 21477957(2,3-Difluoro-4-nonylphenyl)boronic acid

実験手順

Quantities: compound from Example 26 (35.5 g, 0.15 mol), n-butyllithium (15 cm3, 10M in hexanes, 0.15 mol) and triisopropyl borate (56.4 g, 0.3 mol). The experimental procedure was as described in Example 28.

出典と根拠

ORDレコード: ord-12b2eef346b54560b7ded5ff6e13baa2
出典データセット: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05683623

反応ノート

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