Triisopropyl borate → [2,3-Difluoro-4-(heptyloxy)phenyl]boronic acid

反応式

C([Li])CCC.[F:6][C:7]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].[B:22](OC(C)C)([O:27]C(C)C)[O:23]C(C)C>>[F:13][C:12]1[C:7]([F:6])=[C:8]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:9]=[CH:10][C:11]=1[B:22]([OH:27])[OH:23]

参加物

反応物 3

HCID 21531Triisopropyl borate

HCID 214779471,2-Difluoro-3-(heptyloxy)benzene

HCID 178418339Butyllithium

生成物 1

HCID 21477961[2,3-Difluoro-4-(heptyloxy)phenyl]boronic acid

実験手順

Quantities: n-butyllithium (20 cm3, 10.0M in hexanes, 0.2 mol), compound from Example 40 (45.5 g, 0.2 mol) and triisopropyl borate (74.4 g, 0.4 mol). The experimental procedure was as described in Example 28.

出典と根拠

ORDレコード: ord-af23ae372b474ac0926e3d034badfe5f
出典データセット: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05683623

反応ノート

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