1-Bromo-5-chloropentane → HCID 86181973、化合物

HRID 2292499ノート

反応式

HRID 2292499 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[Cl:10])=[CH:4][CH:3]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][Cl:29].[O-]CC.[Na+]>C(O)C>[Cl:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[Cl:10])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 960701-Bromo-5-chloropentaneHCID 2723922Sodium ethoxideHCID 45530804-(2-Chloro-1,2-diphenylethenyl)phenol

生成物 1

HCID 86181973HCID 86181973、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Combine (E and Z)-1-[(4-hydroxy)phenyl]-1,2-diphenyl-2-chloro-ethylene (2.3 g, 7.5 mmol) and 5-bromo-1-chloropentane (2.78 g, 15.0 mmol) in ethanol (40 mL). Add a solution of sodium ethoxide in ethanol (11.12 mL, 0.67M, 7.5 mmol). Heat to reflux under an inert atmosphere. After 24 hours concentrate in vacuo. Chromatograph on silica gel eluting with 1/7 ethyl acetate/hexane. Concentration of the product containing fractions to give the title compound which is taken on to the next step without further purification.

後処理

  1. temperatureHeat
  2. temperatureto reflux under an inert atmosphere
  3. concentrationAfter 24 hours concentrate in vacuo
  4. additionConcentration of the product containing fractions

出典と根拠

ORDレコード
ord-48efa1ddf4f64d71a05c40a4b2c33277
出典データセット
uspto-grants-1997_11
特許番号
US05684004

反応ノート

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