4-oxo-4H-1-benzopyran-2-carbonyl chloride → 2-Benzoyl-4H-1-benzopyran-4-one

HRID 2292626ノート

反応式

HRID 2292626 の反応式
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH:3]=[C:2]1[C:12](Cl)=[O:13].[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[C:12]([C:2]1[O:1][C:10]2[C:5]([C:4](=[O:11])[CH:3]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)(=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 787884-oxo-4H-1-benzopyran-2-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 127520732-Benzoyl-4H-1-benzopyran-4-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Combine chromone-2-carboxylic acid chloride (2.0 g, 9.6 mmol) and aluminum chloride (3.84 g, 28.7 mmol) in benzene (70 mL). Heat at reflux for 4 hours. Pour the reaction mixture into ice-water (150 mL). Extract with dichloromethane twice. Dry the separated organic layers over MgSO4, filter, and evaporate in vacuo. Chromatograph on silica gel eluting with 15% ethyl acetate/hexane. Evaporate the product containing fractions to give the title compound as a solid.

後処理

  1. temperatureHeat
  2. temperatureat reflux for 4 hours
  3. extractionExtract with dichloromethane twice
  4. dry with materialDry the separated organic layers over MgSO4
  5. filtrationfilter
  6. customevaporate in vacuo
  7. customEvaporate the product
  8. additioncontaining fractions

出典と根拠

ORDレコード
ord-3355e4999d794acdbd765d8725b5597a
出典データセット
uspto-grants-1997_11
特許番号
US05684017

反応ノート

読み込み中…