Acetone → HCID 21476885、化合物
反応式
[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH:6]1[O:10][C:9]([NH2:11])=[N:8][CH2:7]1.[CH3:16][C:17]([CH3:19])=O>>[CH2:16]([NH:11][C:9]1[O:10][CH:6]([CH2:5][O:4][C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[CH3:1])[CH2:7][N:8]=1)[CH2:17][CH3:19]参加物
3
実験手順
In a reactor are introduced 0,01 mol of 5-[(2-methylphenoxy)methyl]-4,5-dihydro-oxazol-2-ylamine and 100 ml of acetone. Once dissolution is complete, 0,005 mol of 1-bromopropyl are added and the whole is heated to ebullition during 48 hours. After filtering off the formed solid and evaporating the solvent, the crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5).
後処理
- dissolutionOnce dissolution
- addition0,005 mol of 1-bromopropyl are added
- temperaturethe whole is heated
- filtrationAfter filtering off the formed solid
- customevaporating the solvent
- customthe crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5)
出典と根拠
- ORDレコード
- ord-78e30df230a6459abf46e947c99ac0f8
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05686477
反応ノート
読み込み中…