1-(2-Pyrimidinyl)piperazine → 9-Ethyl-6-fluoro-8-difluoromethoxy-7-[4-(2-pyrimidinyl)piperazin-1-yl]-2,3,4,9-tetrahydroisothiazolo-[5,4-b]quinolin-3,4-dione

HRID 2293977ノート

反応式

HRID 2293977 の反応式
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:18])=[C:10](F)[C:11]=2[O:13][CH:14]([F:16])[F:15])[C:6](=[O:19])[C:5]2[C:20](=[O:23])[NH:21][S:22][C:4]1=2)[CH3:2].[N:24]1[CH:29]=[CH:28][CH:27]=[N:26][C:25]=1[N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:18])=[C:10]([N:33]3[CH2:34][CH2:35][N:30]([C:25]4[N:24]=[CH:29][CH:28]=[CH:27][N:26]=4)[CH2:31][CH2:32]3)[C:11]=2[O:13][CH:14]([F:16])[F:15])[C:6](=[O:19])[C:5]2[C:20](=[O:23])[NH:21][S:22][C:4]1=2)[CH3:2]

参加物

3

反応物 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 214733459-Ethyl-6,7-difluoro-8-difluoromethoxy-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinolin-3,4-dione

生成物 1

HCID 214733539-Ethyl-6-fluoro-8-difluoromethoxy-7-[4-(2-pyrimidinyl)piperazin-1-yl]-2,3,4,9-tetrahydroisothiazolo-[5,4-b]quinolin-3,4-dione収率 1.4%

実験手順

The same reaction as in Example 1 was carried out by using mg (1.44 mmole) of 9-ethyl-6,7-difluoro-8-difluoromethoxy-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinolin-3,4-dione and 1.9 g (11.5 mmole) of 1-(2-pyrimidinyl)piperazine to obtain 10 mg of the title compound as pale yellow powder.

後処理

  1. customThe same reaction as in Example 1

出典と根拠

ORDレコード
ord-977f321bca134b08b231176796157e05
出典データセット
uspto-grants-1997_11
特許番号
US05688791

反応ノート

読み込み中…