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Aniline → 1-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | tert-Butyl 6-Oxa-3-azabicyclo(3.1.0)hexane-3-carboxylate | HCID 10103880 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine | HCID 21473347 | 64.5% |
反応手順
In 20 ml of ethyl alcohol was dissolved 5 g (0.027 mole) of 1-t-butoxycarbonyl-3-epoxypyrrolidine, and 12.6 g (0.135 mole) of aniline was added thereto. The mixture was refluxed by heating for 20 hours. After the mixture was cooled to room temperature, the solvent was removed under reduced pressure, and the residue was applied to silica gel column chromatography (the eluent used was a mixture of ethyl acetate:toluene=1:4) to obtain 4.85 g of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine as yellowish brown crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05688791 |
| 出典データセット | uspto-grants-1997_11 |
| ORD ID | ord-cc48a11a0c6f4f92a7fee401fa3e0cd9 |
| 出典メモ | uspto-grants-1997_11 |