Hydrochloric Acid → 3-Hydroxy-4-phenylaminopyrrolidine hydrochloride
反応式
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1参加物
4
実験手順
In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.
後処理
- customobtained
- additionwas added
- temperatureAfter the mixture was refluxed
- temperatureby heating for 2.5 hours
- customthe solvent was removed under reduced pressure
- washThe resulting residue was washed with ethanol and ether
出典と根拠
- ORDレコード
- ord-00670e6f07064619996405877f3459db
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05688791
反応ノート
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