Hydrochloric Acid → HCID 21473349、化合物

HRID 2293992

反応式

HRID 2293992 の反応式
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 214733471-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine

生成物 1

HCID 21473349HCID 21473349、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.

後処理

  1. customobtained
  2. additionwas added
  3. temperatureAfter the mixture was refluxed
  4. temperatureby heating for 2.5 hours
  5. customthe solvent was removed under reduced pressure
  6. washThe resulting residue was washed with ethanol and ether

出典と根拠

ORDレコード
ord-00670e6f07064619996405877f3459db
出典データセット
uspto-grants-1997_11
特許番号
US05688791

関連ノート

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