Hydrochloric Acid → 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride

HRID 2294009ノート

反応式

HRID 2294009 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1.[ClH:26]>C(O)C>[ClH:26].[ClH:26].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 98623392-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine

生成物 1

HCID 214737112-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride収率 94.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

後処理

  1. customthe residue was recrystallized from ethanol/diethyl ether

出典と根拠

ORDレコード
ord-aa119e3e72dc4c73b0141cc73f0aba92
出典データセット
uspto-grants-1997_11
特許番号
US05688798

反応ノート

読み込み中…