Acetic Acid → HCID 57758602、化合物

反応式

C([O:3][C:4]([C:6]1[C:7]([NH:21][NH2:22])=[N:8][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[N:10][CH:11]=1)=O)C.CC[O-].[Na+].CC(O)=O.O>CCO>[F:20][C:14]1[CH:15]=[C:16]([F:19])[CH:17]=[CH:18][C:13]=1[O:12][C:9]1[N:8]=[C:7]2[NH:21][NH:22][C:4](=[O:3])[C:6]2=[CH:11][N:10]=1

参加物

実験手順

A solution of 2-(2,4-difluoro-phenoxy)-4-hydrazino-pyrimidine-5-carboxylic acid ethyl ester (7.0 g) and NaOEt (21% in EtOH, 16.85 mL) in EtOH (56 mL) was heated to 55° C. for two hours. The reaction was cooled, and HOAc was added to adjust pH to around 5.0. Water was added until no more precipitation occurred, and the mixture was filtered. The precipitate was collected and dried under vacuum to give 6-(2,4-difluoro-phenoxy)-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one (4.7 g).